Survival after surgery among patients with cholangiocarcinoma in Northeast Thailand according to anatomical and morphological classification

Abstract Background Cholangiocarcinoma (CCA) has been categorized based on tumor location as intrahepatic (ICCA), perihilar (PCCA) or distal (DCCA), and the morphology of bile duct mass forming (MF), periductal infiltrating (PI) intraductal (ID). To date, there is limited evidence available regarding survival CCA among these different anatomical morphological classifications. This study aimed to evaluate rate median time after curative surgery patients according their classifications, determine association between classifications survival. Methods included who underwent from Screening Care Program (CASCAP), Northeast Thailand. The were pathological findings surgery. Survival rates since date 95% confidence intervals (CI) calculated. Multiple cox regression was performed factors associated with which quantified by hazard ratios (HR) CIs. Results Of 746 patients, 514 had died at completion constituted 15,643.6 person-months data recordings. incidence 3.3 per 100 month (95% CI: 3.0–3.6), 17.8 months 15.4–20.2), 5-year 24.6% 20.7–28.6). longest 21.8 16.3–27.3) while highest 34.8% 23.8–46.0) occurred in DCCA group. A combination PCCA+ID, 40.5 17.9–63.0) 42.6% 25.4–58.9). ICCA+MF (adjusted HR: 1.45; 1.01–2.09; P = 0.013) compared ICCA+ID patients. Conclusions Among receiving surgical treatment, those PCCA+ID rate, higher than groups classified only characteristics. Additionally, tended have unfavorable outcomes. Showed association. Therefore, further investigations into imaging should focus a